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Erin Giles - Assistant Professor
- Office:
- 214A Cater-Mattil
- Email:
- egiles@tamu.edu
- Phone:
- 979-459-1849
- https://gileslab.tamu.edu/
- Undergraduate Education
- B.Sc. in Bio-Medical Science (Honours)
- University of Guelph, Ontario, Canada, 2000
- Graduate Education
- Ph.D.in Medical Science, McMaster University, Hamilton, Ontario, Canada, 2007
- Postdoctoral Fellowship, Division of Endocrinology, Diabetes & Metabolism, Anschutz Health and Wellness Center, University of Colorado School of Medicine, Aurora, Colorado
- Awards
- 2018-Fellow, 2018 cohort, NCI Transdisciplinary Research on Energetics and Cancer (TREC)
- 2017-Komen Obesity-Breast Cancer Grand Challenge Competition, 2nd Place Award
- 2015-Outstanding Post-Doctoral Fellow, University of Colorado Nutrition Obesity Research Center
- 2014-Colorado Center for Women’s Health Research - Junior Faculty Research Development Award
- 2014-Postdoctoral Fellow of the Year, Division of Endocrinology, Diabetes, & Metabolism, University of Colorado School of Medicine
- 2014-Top Abstract, The Obesity Society – Obesity & Cancer Section
- 2014-Travel Award - Integrating Resistant Starch, Microbiome, and Disease Risk Reduction Symposium
- 2013-Early Career Travel Award, Endocrine Society Annual Meeting
- 2012-Research Recognition Award, American Physiological Society, Integrative Biology of Exercise IV Meeting
- 2012-Winning Poster, University of Colorado Postdoctoral Research Day
- 2010-Colorado Nutrition and Obesity Research Center Pilot Award
- 2010-American Institute for Cancer Research Fellowship
- 2009-Thorkildensen Research Fellowship
- 2009-Early Career Investigator Travel Award, Kern Aspen Lipid Conference
- 2009-Travel Award, FASEB Summer Research Conference - The Physiological Basis for Obesity Therapeutics
- 2008-University of Colorado Denver, School of Medicine Research Day 1st place - Postdoctoral Fellows Category
- 2006-McMaster University Department of Oncology Residents Research Day 1st place (oral)
- 2003-Canadian Breast Cancer Foundation Research Fellowship
- 2003-Travel Award, Gordon Research Conference - Insulin-Like Growth Factors in Physiology & Disease, Scholar
- 2001-2003 -Ontario Graduate Scholarship
- 2000-2001-Graduate Scholarship, McMaster University
- 1999-Undergraduate Research Fellowship Award, University of Guelph
Research Interest
I am currently building a research program that uses an integrative, translational approach to understand the mechanisms by which obesity promotes postmenopausal breast cancers. My work focuses on understanding how the obese microenvironment, when combined with the metabolic and hormonal changes associated with menopause, promote tumor development, survival, and growth. In parallel, I am investigating the role of adipose tissue inflammation in the development of metabolic disease after menopause. My hope is that the knowledge gained from studying the ‘normal’ adipose and breast environments during menopause will also help us understand the changes that occur to create a tumor-promoting environment in the breast of obese women during this same window of time.
Publications
- Fabian, CJ, Klemp, JR, Marchello, NJ, Vidoni, ED, Sullivan, DK, Nydegger, JL et al.. Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors. Cancers (Basel). 2021;13 (19):. doi: 10.3390/cancers13194871. PubMed PMID:34638355 PubMed Central PMC8508448.
- Glenny, EM, Coleman, MF, Giles, ED, Wellberg, EA, Hursting, SD. Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer. Annu Rev Nutr. 2021;41 :253-282. doi: 10.1146/annurev-nutr-120420-032437. PubMed PMID:34357792 .
- Fabian, CJ, Befort, CA, Phillips, TA, Nydegger, JL, Kreutzjans, AL, Powers, KR et al.. Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight-Loss Intervention Randomized to High-Dose ω-3 Fatty Acids versus Placebo. Cancer Prev Res (Phila). 2021;14 (9):893-904. doi: 10.1158/1940-6207.CAPR-20-0656. PubMed PMID:34244155 PubMed Central PMC8416797.
- Giles, ED, Wellberg, EA. Preclinical Models to Study Obesity and Breast Cancer in Females: Considerations, Caveats, and Tools. J Mammary Gland Biol Neoplasia. 2020;25 (4):237-253. doi: 10.1007/s10911-020-09463-2. PubMed PMID:33146844 PubMed Central PMC8197449.
- Giles, ED, Brown, IL, MacLean, PS, Pan, Z, Melanson, EL, Heard, KJ et al.. The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. Nutrients. 2019;11 (10):. doi: 10.3390/nu11102484. PubMed PMID:31623184 PubMed Central PMC6835355.
- Presby, DM, Checkley, LA, Jackman, MR, Higgins, JA, Jones, KL, Giles, ED et al.. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019;317 (5):R684-R695. doi: 10.1152/ajpregu.00074.2019. PubMed PMID:31553623 PubMed Central PMC6879845.
- Sherk, VD, Jackman, MR, Higgins, JA, Giles, ED, Foright, RM, Presby, DM et al.. Impact of Exercise and Activity on Weight Regain and Musculoskeletal Health Post-Ovariectomy. Med Sci Sports Exerc. 2019;51 (12):2465-2473. doi: 10.1249/MSS.0000000000002082. PubMed PMID:31274683 PubMed Central PMC7194137.
- Giles, ED, Jindal, S, Wellberg, EA, Schedin, T, Anderson, SM, Thor, AD et al.. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res. 2018;20 (1):50. doi: 10.1186/s13058-018-0974-2. PubMed PMID:29898754 PubMed Central PMC6000949.
- Wellberg, EA, Checkley, LA, Giles, ED, Johnson, SJ, Oljira, R, Wahdan-Alaswad, R et al.. The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer. Horm Cancer. 2017;8 (5-6):269-285. doi: 10.1007/s12672-017-0302-9. PubMed PMID:28741260 PubMed Central PMC6022404.
- Sherk, VD, Jackman, MR, Giles, ED, Higgins, JA, Foright, RM, Presby, DM et al.. Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function. Physiol Rep. 2017;5 (10):e13272. doi: 10.14814/phy2.13272. PubMed PMID:28533263 PubMed Central PMC5449558.