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Xie, Linglin

Linglin Xie

Associate Professor Department of Nutrition
Office:  
217B Cater-Mattil, College Station, Texas
Email:  
Phone:  
979-321-7065
Resume/CV
Graduate Education
Huazhong University of Science and Technology, China, 2000 MD, Tongji Medical College
Kansas State University, Manhattan, KS, 2004 M.S. in Human Nutrition
Kansas State University, Manhattan, KS, 2008 Ph.D. in Molecular, Cellular and Developmental Biology
University of Chicago, Chicago,IL, 2011 Postdoctoral in Pediatrics
Courses Taught
NUTR 481

Professional Summary

Research Area

Throughout her research career, Dr. Xie has dedicated herself to exploring various facets within the field of nutrition, developmental biology, and their implications for human health. Her primary focus is investigating the complex interplay between maternal factors, environmental exposures, and their effects on offspring health. Specifically, her interests encompass four major fields: (1) examining the impact of maternal nutrition on offspring obesity and metabolic dysfunction-associated fatty liver disease (MAFLD); (2) gaining an understanding of the molecular mechanisms underlying liver cancer; (3) studying the interactions between environmental and maternal factors in promoting healthy pregnancy and offspring development; (4) exploring the regulatory gene network involved in heart development.

  1. Ding, Z, McCauley, N, Qin, Y, Lawless, L, Guo, S, Zhang, L et al.. FoxO1 Deficiency Enhances Cell Proliferation and Survival Under Normoglycemia and Promotes Angiogenesis Under Hyperglycemia in the Placenta. Lab Invest. 2023;103 (1):100017. doi: 10.1016/j.labinv.2022.100017. PubMed PMID:36748194 .
  2. Xie, L, Tang, W, Lin, H, Lei, F, Chen, Y, Wang, Y et al.. Apparent Deterioration Law and Shear Failure Mode of Rock-Mortar Interface Based on Topography-Sensing Technology. Materials (Basel). 2023;16 (2):. doi: 10.3390/ma16020763. PubMed PMID:36676502 PubMed Central PMC9863133.
  3. Liu, L, Zhou, Y, Liu, Z, Li, J, Hu, L, He, L et al.. Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression. Cell Mol Gastroenterol Hepatol. 2022; :. doi: 10.1016/j.jcmgh.2022.12.010. PubMed PMID:36581078 .
  4. Peng, H, Li, J, Xu, H, Wang, X, He, L, McCauley, N et al.. Offspring NAFLD liver phospholipid profiles are differentially programmed by maternal high-fat diet and maternal one carbon supplement. J Nutr Biochem. 2023;111 :109187. doi: 10.1016/j.jnutbio.2022.109187. PubMed PMID:36270572 .
  5. Xu, Y, Tran, L, Tang, J, Nguyen, V, Sewell, E, Xiao, J et al.. FBP1-Altered Carbohydrate Metabolism Reduces Leukemic Viability through Activating P53 and Modulating the Mitochondrial Quality Control System In Vitro. Int J Mol Sci. 2022;23 (19):. doi: 10.3390/ijms231911387. PubMed PMID:36232688 PubMed Central PMC9570078.
  6. Li, H, Zheng, J, Xu, Q, Yang, Y, Zhou, J, Guo, X et al.. Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation. Gastroenterology. 2023;164 (1):134-146. doi: 10.1053/j.gastro.2022.09.027. PubMed PMID:36181835 PubMed Central PMC9772177.
  7. He, L, Wang, X, Ding, Z, Liu, L, Cheng, H, Bily, D et al.. Deleting Gata4 in hepatocytes promoted the progression of NAFLD via increasing steatosis and apoptosis, and desensitizing insulin signaling. J Nutr Biochem. 2023;111 :109157. doi: 10.1016/j.jnutbio.2022.109157. PubMed PMID:36150682 .
  8. Xiong, X, Cheng, Z, Zhou, Y, Wu, F, Xie, L, Lawless, L et al.. HuanglianGanjiang Tang alleviates DSS-induced colitis in mice by inhibiting necroptosis through vitamin D receptor. J Ethnopharmacol. 2022;298 :115655. doi: 10.1016/j.jep.2022.115655. PubMed PMID:35988837 .
  9. McCauley, N, Lawless, L, Basra, M, DePadova, N, Loyola, XA, Zhou, H et al.. In ovo exposure to cadmium causes right ventricle hyperplasia due to cell proliferation of cardiomyocytes. Toxicol Lett. 2022;366 :1-6. doi: 10.1016/j.toxlet.2022.06.007. PubMed PMID:35753640 .
  10. Peng, H, Xu, H, Wu, J, Li, J, Wang, X, Liu, Z et al.. Maternal One-Carbon Supplement Reduced the Risk of Non-Alcoholic Fatty Liver Disease in Male Offspring. Nutrients. 2022;14 (12):. doi: 10.3390/nu14122545. PubMed PMID:35745277 PubMed Central PMC9228996.
  11. Hino, C, Pham, B, Park, D, Yang, C, Nguyen, MHK, Kaur, S et al.. Targeting the Tumor Microenvironment in Acute Myeloid Leukemia: The Future of Immunotherapy and Natural Products. Biomedicines. 2022;10 (6):. doi: 10.3390/biomedicines10061410. PubMed PMID:35740430 PubMed Central PMC9219790.
  12. Lynch, EC, Liu, Z, Liu, L, Wang, X, Zhang, KK, Xie, L et al.. Disrupting Osr1 expression promoted hepatic steatosis and inflammation induced by high-fat diet in the mouse model. PLoS One. 2022;17 (6):e0268344. doi: 10.1371/journal.pone.0268344. PubMed PMID:35657825 PubMed Central PMC9165803.

Search PubMed

  1. Q. Fu, P. Olson, D. Rasmussen, M. Williamson, B. Keith, K. K .Zhang, L. Xie. A Short-Term Transition from a High-Fat Diet to a Normal-Fat Diet Before Pregnancy Exacerbates Female Mouse Offspring Obesity. Int J Obes (Lond). 2015 Nov 26. doi: 10.1038/ijo.2015.236.
  2. Y. Zhou and L. Xie. High Fat Diet Mouse Model in the Study of Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma. Am J Digest Dis; 2(1): 60-65, 2015
  3. Q. Fu, K.K. Zhang, L. Xie. A meta-analysis of case-control studies of high-fat diet and colorectal cancer. Am J Digest Dis;1(2):127-135, 2014