Rosemary Walzem

Professional Summary

Dr. Walzem’s core research focus within the laboratory is directed towards understanding how the structure of triglyceride-rich lipoproteins influences their ability to carry out specific nutrient delivery tasks. Her studies include identification of mechanisms and regulatory processes that control the assembly of trigylceride-rich lipoproteins in issues, structural studies of lipoproteins themselves and physiological studies to determine substrate properties and metabolic fates of different types of lipoproteins. Diet can significantly alter lipoprotein physiology through multiple mechanisms, and studies of diet effects provides a significant sub-theme to the research program. A variety of species are used to address specific questions, however, avian and human lipoprotein metabolism as it relates to egg production and atherogenesis, respectively, are emphasized.

Selected Publications

• Guo X, Li H, Xu H, Halim V, Zhang W, Wang H, Ong KT, Woo SL, Walzem RL, Mashek DG, Dong H, Lu F, Wei L, Huo Y & Wu C (2012)  Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice. PLoS One 7: e39286
• Heinze CR, Hawkins MG, Gillies LA, Wu X, Walzem RL, German JB & Klasing KC (2012)  Effect of dietary omega-3 fatty acids on red blood cell lipid composition and plasma metabolites in the cockatiel, Nymphicus hollandicus. J Anim Sci
• Pan YE, Liu ZC, Chang CJ, Xie YL, Chen CY, Chen CF, Walzem RL & Chen SE (2012)  Ceramide accumulation and up-regulation of proinflammatory interleukin-1β exemplify lipotoxicity to mediate declines of reproductive efficacy of broiler hens. Domest Anim Endocrinol 42: 183-94
• Gilmore LA, Walzem RL, Crouse SF, Smith DR, Adams TH, Vaidyanathan V, Cao X & Smith SB (2011)  Consumption of high-oleic acid ground beef increases HDL-cholesterol concentration but both high- and low-oleic acid ground beef decrease HDL particle diameter in normocholesterolemic men. J Nutr 141: 1188-94
• Wagner EL, Potter GD, Gibbs PG, Eller EM, Scott BD, Vogelsang MM & Walzem RL (2011)  Copper and zinc balance in exercising horses fed 2 forms of mineral supplements. J Anim Sci 89: 722-8
• Weinstein MM, Tu Y, Beigneux AP, Davies BS, Gin P, Voss C, Walzem RL, Reue K, Tontonoz P, Bensadoun A, Fong LG & Young SG (2010)  Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice. Arterioscler Thromb Vasc Biol 30: 2106-13
• Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP & Young SG (2010)  Chylomicronemia elicits atherosclerosis in mice–brief report. Arterioscler Thromb Vasc Biol 30: 20-3
• Adams TH, Walzem RL, Smith DR, Tseng S & Smith SB (2010)  Hamburger high in total, saturated and trans-fatty acids decreases HDL cholesterol and LDL particle diameter, and increases TAG, in mildly hypercholesterolaemic men. Br J Nutr 103: 91-8
• Beigneux AP, Franssen R, Bensadoun A, Gin P, Melford K, Peter J, Walzem RL, Weinstein MM, Davies BS, Kuivenhoven JA, Kastelein JJ, Fong LG, Dallinga-Thie GM & Young SG (2009)  Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase. Arterioscler Thromb Vasc Biol 29: 956-62
• Gorman KB, Esler D, Walzem RL & Williams TD (2009)  Plasma yolk precursor dynamics during egg production by female greater scaup (Aythya marila): Characterization and indices of reproductive state. Physiol Biochem Zool 82: 372-81
• Walzem RL (2008)  Wine and health: state of proofs and research needs. Inflammopharmacology 16: 265-71
• Johnson LA, Altenburg MK, Walzem RL, Scanga LT & Maeda N (2008)  Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequences. Arterioscler Thromb Vasc Biol 28: 1745-52
• Wang L, Yu J & Walzem RL (2008)  High-carbohydrate diets affect the size and composition of plasma lipoproteins in hamsters (Mesocricetus auratus). Comp Med 58: 151-60
• Walzem RL & Murano P (2008)  Societal aspects in the dietary management of childhood hyperlipidemia. J Clin Lipidol 2: 156-61
• Walzem RL, Baillie RA, Wiest M, Davis R, Watkins SM, Porter TE, Simon J & Cogburn LA (2007)  Functional annotation of genomic data with metabolic inference. Poult Sci 86: 1510-22
• Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A & Young SG (2007)  Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons. Cell Metab 5: 279-91
• Salvante KG, Walzem RL & Williams TD (2007)  What comes first, the zebra finch or the egg: temperature-dependent reproductive, physiological and behavioral plasticity in egg-laying zebra finches. J Exp Biol 210: 1325-34
• Salvante KG, Lin G, Walzem RL & Williams TD (2007)  Characterization of very-low density lipoprotein particle diameter dynamics in relation to egg production in a passerine bird. J Exp Biol 210: 1064-74